Prognostic significance of immune function parameters in patients with chronic lymphocytic leukaemia

Prognostic Significance of Immune Function Parameters (CD4, CD8 and CD4/CD8 ratio) in Sudanese Patients with Chronic Lymphocytic leukemia

Background: Chronic Lymphocytic Leukemia (CLL) is a heterogeneous disorder with respect to its clinical course. Accurate identification of prognostic factors is becoming increasingly important in order to determine those patients requiring aggressive treatments. The Rai clinical staging systems is used to define disease extent and predict survival. Aim: to evaluate prognostic significance of CD...

Prognostic factors in chronic lymphocytic leukaemia (CLL)

Intravenous immune globulin in chronic lymphocytic leukaemia.

The most common complication of chronic lymphocytic leukaemia (CLL) is infection, which occurs mainly in advanced stages of disease or in those patients with hypogammaglobulinaemia. Intravenous immune globulin (IVIG) has been shown to be a useful prophylactic therapy against infections in such patients. A randomized, double-blind study on 36 patients receiving either 500 mg/kg or 250 mg/kg IVIG...

Lipoprotein lipase: a new prognostic factor in chronic lymphocytic leukaemia

The clinical course of patients with chronic lymphocytic leukemia (CLL) is highly heterogeneous. Gene expression analyses have revealed that leukemic cells with unmutated immunoglobulin heavy chain genes (IgV H ) differ from CLL cells with mutated IgV H in the expression level of some genes, i.e. encoding kinase ZAP-70 and antigen CD38. Recently, additional markers in CLL, including the express...

Small intestinal bacterial overgrowth in patients with chronic lymphocytic leukaemia.

As part of a study to assess the possible contribution of lymphoid infiltration of the gastrointestinal mucosa to occult blood loss or malabsorption 20 patients with chronic lymphocytic leukaemia (CLL) had a lactulose hydrogen breath test. In 10 cases (50%) a small intestinal peak was detected, suggesting small bowel bacterial overgrowth, and this was confirmed in seven patients by the positive...